does blood type affect covid vaccine side effects does blood type affect covid vaccine side effects

What Are the Differences Between the Pfizer and Moderna COVID-19 Vaccines? Omicron vs. Delta: How the 2 COVID-19 Variants Compare, ShinglesHerpes ZosterInfection May Be Linked to the COVID-19 Vaccine. The information in this story is accurate as of press time. "I encourage people who have had COVID once, or even multiple times to still seek out vaccination, as it's going to really optimize the level of protection that you have against getting COVID yet again this fall and winter," he advises. The first hint of a possible relationship came in March, from researchers in China, who compared nearly 2,200 hospitalized COVID-19 patients to a control group of approximately 27,000 healthy individuals. Association between ABO and Rh blood groups and SARS-CoV-2 infection or severe COVID-19 illness. All in all, more than 1 million people were involved. Fatigue. When side effects occur, they typically last just a few days. Why? Common side effects included: tenderness at the injection site for 73% of participants. However, cases remain very rare: the MHRA noted 79 cases of blood clots with low platelets, including 19 deaths, following more than 20m doses of the AstraZeneca jab, with 44 of the cases and 14 of the deaths related to a rare type of blood clot in the brain called cerebral venous sinus thrombosis (CVST) that occurred with a low platelet count. Reactions occurred from the day of administration to 5 days later and lasted 1 to 6 days. Secondary outcome results indicated that type O blood group had an aRR of 0.87 (95% CI, 0.78-0.97) for severe COVID-19 illness and death versus all other blood groups and Rh- status had an aRR of 0.82 (95% CI, 0.680.96) compared to Rh+ status. UNMC researcher Rebekah Gundry, PhD, received a "COVID-19 and Its Cardiovascular Impact Rapid Response Grant" from the American Heart Association in May of 2020. There have been multiple studies on blood types and COVID-19 risk. However, for the Pfizer jab the reverse appears to be true. Laboratory tests 1 week later, as symptoms were resolving, showed >4 g/dL hemoglobin decrease from his baseline. In large clinical trials, most side effects have been minor. In fact, fewer than 57% of all Americans know their blood type, according to a 2019 survey from Quest Diagnostics. Or, they suggest, perhaps the genes associated with blood type also have some effect on the ACE2 receptor, the protein that allows the SARS-CoV-2 virus to infect human cells. But how? Health's content is for informational and educational purposes only. But recently, the genetics company 23andMe revealed preliminary data from their own study showing that a persons blood type, which is determined by the ABO gene, appears to affect susceptibility to coronavirus. "We are learning a lot about coronavirus infection and the impact it has on the heart and vascular system," says Dr. Anderson. To test the effect of the SARS-CoV-2 spike protein on hemolysis, we performed erythrocyte lysis using erythrocytes from a patient with PNH and acidified normal human serum (aNHS) with addition of the SARS-CoV-2 spike protein subunit 1 (S1) (see supplemental methods, available on the Blood Web site). denotes no information is available; AST, aspartate amino transferase; LDH, lactate dehydrogenase; N/A, not applicable; RBC red blood cell. People may. But for young adults that equation, at least at present, is less clearcut. Yet these risks are relative, meaning people with type O blood are not immune to COVID-19. We may earn commission from links on this page, but we only recommend products we back. Those with A or AB type blood also tended to stay longer in the hospitals intensive care units (ICU). The relative protective effects of O, Rh-, and O- blood groups were greatest in patients younger than age 70. However, there are lots of symptoms you can have after a COVID-19 infection, including: problems with your memory and concentration ("brain fog") chest pain or tightness. Headaches. It may also offer a little more peace of mind if youre exposed or do get infected. Patient 1 had a presumptive thrombotic manifestation. The most common symptoms of long COVID are: extreme tiredness (fatigue) shortness of breath. The posts claim that the FDA warns that death is a side effect of the COVID-19 vaccines. Differences in how people have reacted to COVID-19and whyhave occupied researchers throughout the pandemic. One study published in the Journal of the American Medical Association (JAMA) in April of 2021, reviewed nearly 108,000 COVID-19 cases. Regardless of if a specific blood type is associated with a greater risk of contracting COVID-19 and developing severe disease, keep in mind that many other factors, such as age or existing health conditions, are likely to play a larger, dominant role in determining personal risk from COVID-19. The risk for individuals for Type O blood appeared to be significantly lower, just 26 percent of the cases versus 34 percent of the healthy control group. Visit the MHRA Yellow Card report for the latest data on the reported side effects of Covid-19 vaccines. The blood type-infection connection is not unique to the coronavirus. However, the results have been inconsistent and so the connection between COVID-19 and different blood types still isn't clear. S1 did not increase hemolysis of PNH erythrocytes as compared with aNHS alone (Figure 1). On the evening after his first dose of the Pfizer-BioNTech vaccine, he experienced fever, headache, myalgia, and severe fatigue, which lasted 6 days. "Most side effects are mild or moderate and . Our clinicians do not order blood typing routinely, other than for pregnant patients. Fever or chills. It was through these findings, that the Danish researchers suggested: "That blood group O is significantly associated with reduced susceptibility to SARS-CoV-2 infection.". Quite a bit of research has been published on the topic of blood type and its role in determining COVID-19 risk. Cambridge, MA 02142, MIT Lincoln Laboratory "We do not expect [the public] to experience anything that would be out of the ordinary from our experience with the original vaccination.". They have also been shown to be very good at lowering the risk of getting very sick, being hospitalized, or dying from COVID-19 if you are infected. Immunothrombotic dysregulation in COVID-19 pneumonia is associated with respiratory failure and coagulopathy, Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19, Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition, Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine, Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine, How I treat paroxysmal nocturnal hemoglobinuria, SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2, Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome, Heparan sulphate identified on human erythrocytes: a Plasmodium falciparum receptor, Anti-complement treatment for paroxysmal nocturnal hemoglobinuria: time for proximal complement inhibition? Read said that for some people the process was without symptoms, but for others it generated these common side-effects. Youve viewed {{metering-count}} of {{metering-total}} articles this month. In patients with severe disease, deposition of terminal complement and microthrombosis have been observed in the lung, skin, kidney, and heart.14 Recently, we demonstrated that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein leads to amplification of the alternative pathway of complement on cell surfaces through competition with complement factor H (CFH) for binding heparan sulfate.5 Thus, in vitro, the SARS-CoV-2 spike protein can convert an inactivator surface to an activator surface on nucleated cells. Blood type may influence other infections, as well. Patient characteristics and reactions to the COVID-19 vaccines are shown in Table 1. Patients 5 and 6 received both doses of the Pfizer-BioNTech BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine without clinical or laboratory signs of hemolysis. After being vaccinated, it's common and normal to have temporary side effects, even after a COVID-19 infection. ), and the Jack LevinC. Investigators also suggested further research on how ABO status may moderate venous thromboembolism occurrence, a known complication of COVID-19, since blood group O patients have been associated with a decreased risk of venous thromboembolism in prior research. Information on this website is provided for informational purposes only and is a result of years of practice and experience by the author. Specifically, they sought out folks in the U.S. diagnosed and hospitalized with COVID-19. Others have side effects that affect their ability to do daily activities. Addition of 40% aNHS with various concentrations of the spike protein to type O-positive erythrocytes from a patient with PNH (49% PNH red blood cell clone: 25% type III and 24% type II cells) and type O-positive erythrocytes from a healthy control, incubated at 37C for 1 hour. None of these patients were previously transfused in the past year. It's also helpful to know your blood typespecifically the Rh factorduring pregnancy, so your doctor can troubleshoot if the unborn baby has a different Rh factor. Studies of the accuracy of serologic tests for anti-SARS-CoV-2 immunoglobulins may assess whether there is variation in antibody titers by ABO and Rh status, the authors noted. associate medical director of infection prevention at UCI Health and a professor at the University of California, Irvine, posits an analogy that this bivalent vaccine is like a riff on a standard brownie recipe: "You're going to have almost the same ingredients, and bake it for the same time at the same temperature but this time, instead of just chocolate chips, you add dark chocolate, too," she tells Good Housekeeping. Another recently published study, this time co-authored by Canadian Blood Services chief scientist, Dr. Dana Devine, revealed that people with blood groups A or AB were more likely to have a severe case of COVID-19 compared to those with O or B type blood.4. Should you eat before? People react differently after being vaccinated. Investigators conducted a population-based, retrospective cohort study of 225,556 patients who had their ABO blood group assessed between January 2007 and December 2019, and subsequently tested for SARS-CoV-2 between January 15 and June 30, 2020. The chances of any of these side effects occurring after vaccination differ according to the specific vaccine. 15 Ravulizumab, a new C5 inhibitor with a half-life 4 times longer than eculizumab, is reported to have significantly fewer instances of pharmacokinetic breakthrough hemolysis. Here's What You Need to Know, People With Food Allergies May Have Lower Risk of COVID-19 Infection, What To Do About a Lingering Cough After COVID, New Omicron Booster Side Effects: What to Expect From the Bivalent Vaccines. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal, or homeopathic supplement, or using any treatment for a health problem. Conflict-of-interest disclosure: R.A.B. The risk of death was increased for type AB and decreased for types A and B. Side effects may even feel like flu and might affect your ability to do daily. COVID vaccines may have some side effects. This news story has not been updated since the date shown. Both of these studies were posted to the MedRxiv website, where researchers share preliminary, unpublished data, before it has undergone peer review. For the AstraZeneca jab, it seems such side-effects are more common after the first shot. Side effects after getting a COVID-19 vaccine can vary from person to person. There's no need to worry about any of the flu-like symptoms. Do not disregard professional medical advice or delay in seeking professional advice because of something you have read on this website. In both trials, the most commonly reported side effects within a week of injection were: According to current FDA publications, there's also a chance that swelling may occur in lymph nodes within the same arm as the injection site. I have read that people with certainbloodtypes are more susceptible to contracting COVID-19. In short, it might feel like you have the flu. Say, for example, you and your friend who have the same susceptibility are both sharing a bus with someone who has asymptomatic COVID-19. These usually last from a few hours to a few days after vaccination. It is not clear to me why. The company commissioned a huge study, even recruiting people outside of their already massive 23andMe genetics database. "As an individual, you have your blood typethere's nothing you can do about it.". Registration is free. The other common side-effects the muscle aches, flu-like illness and fatigue are probably due to generalised activation of the immune system caused by the vaccine. This unusual clotting may cause different complications, including organ damage, heart attack and stroke. Erythrocyte lysis with addition of the SARS-CoV-2 spike protein S1. "Masks are important because they filter out some of the virus and decreases the viral load, which makes the infection less severe," says Dr. Anderson. Your blood type may also affect how severe the progression of COVID-19 will be. Those two factors make up the eight most common blood types: A+, A-, B+, B-, O+, O-, AB+, and AB-. For the primary outcome, analyses were further stratified by patients aged younger than 70 years vs 70 years or older. The MHRA noted 79 cases of blood clots with low platelets, including 19 deaths, following more than 20m doses of the AstraZeneca jab. There was also a moderately increased risk of infection in people with Rh-positive blood type. The clots linked to the vaccine were a dangerous type in the brain, while birth control pills increase the chances of a blood clot in the leg or lung a point quickly noted by many experts. Symptoms of long COVID. We don't know the answer, which is why ongoing research is so important. Virologists and vaccine experts explore what we know below. Headache. A Top Derm Explains, 35 of the Smartest Fast-Food Choices You Can Make, Easy Brain Exercises to Boost Your Memory, Why We Should All Be Eating More Buckwheat, COVID-19 Emergency Funding Is Coming to an End. Information contained in this story may be outdated. In April, researchers at Columbia University reported similar risks associated with Type A blood after blood-typing more than 1,500 New Yorkers and testing them for COVID-19. According to Australian data collected on the influenza vaccine in 2020, only 5.5% of people reported any adverse event, with just 0.3% being serious enough to see a doctor about. Register for free and gain unlimited access to: - Clinical News, with personalized daily picks for you Its not obvious why this should be perhaps younger people have a much more robust reaction to the priming by the first dose, said Read. There is a higher risk of myocarditis from COVID itself than there is from . should be listed as a very rare side-effect of the vaccine, adults under the age of 30 should be offered alternative Covid vaccines, under way into the Johnson & Johnson (J&J) Covid jab. Muscle aches. "Reassuring the public that everything is being done . He also developed hemoglobinuria on postvaccination days 1 and 2, associated with 2.7 g/dL hemoglobin decrease. Use our Culture Starter to keep home fermenting simple and safe. muscle aches. Concerns have been raised about a particular situation whereby certain blood clots have occurred together with low levels of platelets tiny cells in the blood that help it to clot. Computed tomography with contrast showed peripancreatic fat stranding with normal lipase, concerning for possible small bowel microvascular thrombosis. Some less common side effects include nausea and swollen lymph nodes (especially in the armpit). The relative protective effects of O, Rh-, and O- blood groups were greatest in patients younger than age 70. The pancreas that's at risk of Type 2 diabetes isn . Scientists have readily admitted that this particular batch of bivalent vaccines, targeted towards BA.4 and BA.5 sub-Omicron variants, have yet to be studied in humans officially. If you have or suspect that you have a medical problem, contact your healthcare provider promptly. Some research findings have suggested that people with blood types A and AB are more susceptible to contracting. The Food and Drug Administration sees a possible risk of Guillain-Barre syndrome with Pfizer 's RSV vaccine for older adults and has asked the company to conduct a safety study if the shot is . Dr. Isaac Bogoch discusses the study that examines the risk and severity of COVID-19 and different . Reported side effects of COVID-19 vaccines have mostly been mild to moderate and have lasted no longer thana few days. Now, a "Covid arm" is different from a skin reaction that . Sleep expert Dr. Michael Breus strongly advises that getting a good nights sleep is essential before you go in for the vaccine in order to build a healthy antibody response.7. And if you didn't experience any side effects at all during your initial vaccine series or from the boosters after, there's a good chance you won't this time around, either. It's expected that the likelihood of severe side effects caused by COVID-19 vaccines will decrease as patients receive more boosters over the next few years, Dr. Brown explains. Blood clot symptoms and when they're likely to occur. Although many vaccines can lead to hemolysis and thrombosis in PNH, this effect is mitigated in most patients on complement inhibitors.15 Ravulizumab, a new C5 inhibitor with a half-life 4 times longer than eculizumab, is reported to have significantly fewer instances of pharmacokinetic breakthrough hemolysis.16 Furthermore, 3 instances of breakthrough hemolysis occurred 4 weeks from the last ravulizumab infusion, making suboptimal C5 inhibition unlikely. Since those studies, a fair amount of research has been conducted on blood type and COVID-19 risk. Patients were aged 25 to 63 years, had PNH granulocyte clones of 80%, and had not received transfusions in the past year. According to the AstraZeneca product monograph, more than one in 10 people will experience some of these very common side-effects: Pain or itching at the injection site. In populations at high-risk for exposure, such as healthcare workers, essential workers, and people exposed to a known case of the disease, the O blood type had an even greater protective effect, reducing the risk of acquiring the virus by 19 percent. 4. headache, muscle pain, joint pain. Chills. Copyright 2023 Haymarket Media, Inc. All Rights Reserved. Approximately 12 hours after receiving the second dose of the Moderna mRNA-1273 COVID-19 vaccine, she had a fever (39C) and rigors. These acute stressors are like a "treadmill test for the pancreas," and the pancreas fails. Information and statements regarding dietary supplements/products have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. 2. A protein called the Rh factor can also be present (+) or absent (-) from the blood. Many people have reported side effects, such as headache, fatigue, and soreness at the injection site, that are generally mild to moderate and go away within a few days. As a result the UKs Joint Committee on Vaccination and Immunisation (JCVI) has recommended that adults under the age of 30 should be offered alternative Covid vaccines if available provided they were healthy and at low risk of Covid. However, the chance of developing severe illness and death after a COVID-19 infection is much higher (2-10%). Deep, healing sleep, reducing stress, walking or other forms of gentle exercise, plus pampering yourself, are important for helping to create a robust immune system. Read said: Usually if you have experienced a natural infection in this case with the coronavirus and are then challenged with something that looks quite similar in this case the vaccine an efficient immune system responds very quickly to the second challenge.. Based on these observations, we sought to evaluate whether the SARS-CoV-2 spike protein directly leads to increased hemolysis. A Vancouver study revealed people with blood types A, B or AB had worse outcomes than others. Possible side effects: The side effects are similar to Pfizer-BioNTech's vaccine: Pain, redness, or swelling at the site where the shot was administeredand/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. For the most up-to-date information on COVID-19, please visit online resources provided by the CDC, WHO, and your local public health department. All the evidence we have is that there isnt a correlation, said Simon Kroll, professor of paediatrics and molecular infectious diseases at Imperial College London. When compared with the first dose, adverse reactions reported after the second dose were milder and reported less frequently, the MHRA noted. Some research findings have suggested that people with blood types A and AB are more susceptible to contracting COVID-19, while those with blood type O are less likely to test positive for the virus. In addition to the lungs, blood clots, including those associated with COVID-19, can also harm: The nervous system. Blood type has been identified as a risk factor in many diseases, from cancer to venous and arterial thromboembolism. The remaining authors declare no competing financial interests. Other countries have taken different approaches: in France the AstraZeneca jab is now only to be given to those aged 55 and over, while in Germany it is offered to those aged 60 and over. This material may not be published, broadcast, rewritten or redistributed in any form without prior authorization. Hear the whys of three Black colleagues from Nebraska Medicine. Download Some of the potential side effects of a vaccine - fever, chills, headache and fatigue - can seem very similar to the symptoms of the illness it's meant to prevent. Experts aren't expecting a dramatic shift in side effects triggered by new COVID-19 bivalent booster vaccines targeted toward Omicron spread. However, experts say it is too soon to be sure the J&J jab is causing the blood-clotting problem, and even if it is, the risk is very low. This is why learning from Body Ecology, from doctors, and from other practitioners in our space is important. Data collected by the FDA for earlier bivalent COVID-19 booster vaccines suggests that these shots successfully provided immunogenicity (a boost to your immunity!) If you download your genome as raw data from 23andMe and run it through software, such as Promethease, you can find out whether you have the wild type or a variant of rs505922. It's important to note that individuals will react to these bivalent booster vaccines differently while the most common side effect is pain or swelling at the injection site, many people may feel more severe side effects, and unique combinations of the symptoms listed above. "I expect the COVID-19 booster shot to become an annual recommendation with small changes needed each year to keep up with, and protect against, new variants that arise," she explains. She was also part of a clinical trial with danicopan, an oral complement factor D inhibitor. VITT seems to occur five to 13 days after vaccination with the J&J or AstraZeneca-Oxford shots - after the normal vaccine side effects have . Lockard Conley Research Fellowship in Benign Hematology (G.F.G.). Please login or register first to view this content. Correspondence: Robert A. Brodsky, Division of Hematology, School of Medicine, Johns Hopkins University, 720 Rutland Ave, Ross Research Bldg, Room 1025, Baltimore, MD 21205; e-mail: [email protected]. "Some evidence shows the severity of the infection is associated with different blood cell types, but the mechanisms by which it happens are unclear," says Dr. Anderson. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. One study of over 3,000 people who got a COVID-19 vaccine did not find any increased side effects or other issues among people with different blood types. A transcript of the podcast is below the summary. The reduction in risk appeared to be about 9 to 18 percent for people with an O blood type compared with other blood types, among which there was little difference in susceptibility. Send it to us [email protected], and well do our best to provide an answer. Do COVID-19 vaccines and boosters raise your blood sugar? For blood types O and B, the average stay was nine days. Early reports that some people had severe allergic reactions, particularly to the Pfizer jab, led the UKs Medicines and Healthcare products Regulatory Agency (MHRA) to offer new recommendations, including that anyone receiving the Pfizer jab be monitored for 15 minutes after the event.